Chemicals and Drugs

Piperazine

An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

Chemical Identity

Chemical Information

Molecular Formula
C4H10N2
Molecular Weight
86.14 g/mol
CAS Registry No.
110-85-0
IUPAC Name
piperazine
InChIKey
GLUUGHFHXGJENI-UHFFFAOYSA-N
SMILES
C1CNCCN1
MeSH Unique ID
D000077489
Source
PubChem CID 4837

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

21 entry terms
  • 1,4-Diazacyclohexane
  • 1,4-Piperazine
  • 1,4 Diazacyclohexane
  • 1,4 Piperazine
  • Piperazine Diacetate
  • Piperazine Dihydrochloride
  • Piperazine Hexahydrate
  • Piperazine Hydrate
  • Piperazine Hydrobromide
  • Piperazine Hydrochloride
  • Piperazine Monohydrochloride
  • Piperazine Phosphate
  • Piperazine Phosphate (1:1)
  • Piperazine Phosphate Anhydrous
  • Piperazine Salt
  • Piperazine Sulfate
  • Piperazine Tartrate
  • Piperazine Tartrate (1:1), (R-(R*,R*))-isomer
  • Piperazine Tartrate, (R-(R*,R*))-isomer
  • Piperazinium Oleate
  • Pripsen

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

PIPERAZINES is also available

MeSH Record

History Note

2019 (1982)

MeSH Hierarchy

Tree Number

  1. D03w.383.606w.768w

AMA Style

References

  1. National Library of Medicine. Piperazine. Medical Subject Headings (MeSH). 2026. Unique ID D000077489. http://id.nlm.nih.gov/mesh/2026/D000077489
  2. Piperazine. In: Wikipedia. https://en.wikipedia.org/wiki/Piperazine
  3. Piperazine. In: Wikidata. https://www.wikidata.org/wiki/Q409292
  4. Piperazine. In: PubChem Compound. CID 4837. https://pubchem.ncbi.nlm.nih.gov/compound/4837