Chemicals and Drugs

Pituitary Adenylate Cyclase-Activating Polypeptide

A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS and VASOACTIVE INTESTINAL PEPTIDE RECEPTOR. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS and VASOACTIVE INTESTINAL PEPTIDE RECEPTOR. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

8 entry terms
  • PACAP
  • Pituitary Adenylate Cyclase Activating Polypeptide
  • PACAP-27
  • PACAP-38
  • PACAP27
  • PACAP38
  • Pituitary Adenylate Cyclase Activating Polypeptide 27
  • Pituitary Adenylate Cyclase Activating Polypeptide 38

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1990)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.860.887
  2. D12.644w.400w.625
  3. D12.776w.467.860.887
  4. D12.776w.631w.600.887
  5. D12.776w.631w.650w.625
  6. D23.529.850.887

AMA Style

References

  1. National Library of Medicine. Pituitary Adenylate Cyclase-Activating Polypeptide. Medical Subject Headings (MeSH). 2026. Unique ID D051219. http://id.nlm.nih.gov/mesh/2026/D051219
  2. Pituitary Adenylate Cyclase-Activating Polypeptide. In: Wikidata. https://www.wikidata.org/wiki/Q6591522