Structured Summary
Abstract
An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.
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Synonyms
10 entry terms
- Factor, Placenta Growth
- Growth Factor, Placenta
- Placenta Growth Factor, PLGF-1 Isoform
- Placenta Growth Factor, PLGF-2 Isoform
- Placenta Growth Factor, PLGF-3 Isoform
- Placenta Growth Factor, PLGF-4 Isoform
- Placenta Growth Factor, PLGF 1 Isoform
- Placenta Growth Factor, PLGF 2 Isoform
- Placenta Growth Factor, PLGF 3 Isoform
- Placenta Growth Factor, PLGF 4 Isoform
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017 (1991)
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AMA Style
References
- National Library of Medicine. Placenta Growth Factor. Medical Subject Headings (MeSH). 2026. Unique ID D000072483. http://id.nlm.nih.gov/mesh/2026/D000072483
- Placenta Growth Factor. In: Wikidata. https://www.wikidata.org/wiki/Q21123270