Chemicals and Drugs

Platelet Factor 4

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Antiheparin Factor
  • CXCL4 Chemokine
  • Chemokine CXCL4
  • Heparin Neutralizing Protein
  • PF4 (Platelet Factor 4)
  • gamma-Thromboglobulin
  • CXCL4, Chemokine
  • Chemokine, CXCL4
  • gamma Thromboglobulin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

84(76); was see under BLOOD COAGULATION FACTORS 1976-83

MeSH Record

Previous Indexing

  • Blood Coagulation Factors (1973-1975)
  • Blood Platelets (1974-1975)
  • Glycoproteins (1974-1975)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.276.374w.200w.120.900
  2. D12.776w.124w.125.720
  3. D12.776w.467.374w.200w.120.900
  4. D23.119.940
  5. D23.125.300w.120.900
  6. D23.469.200w.120.900
  7. D23.529.374w.200w.120.900

AMA Style

References

  1. National Library of Medicine. Platelet Factor 4. Medical Subject Headings (MeSH). 2026. Unique ID D010978. http://id.nlm.nih.gov/mesh/2026/D010978
  2. Platelet Factor 4. In: Wikidata. https://www.wikidata.org/wiki/Q24772397