Chemicals and Drugs

Poly(A)-Binding Protein II

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

7 entry terms
  • PAB II
  • PAB2 Poly(A) Binding Protein
  • PABP2
  • Pabp2 Gene Product
  • Pabp2 Protein
  • Poly(A) Binding Protein II
  • Poly(A) Binding Protein, Nuclear 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002

MeSH Record

Previous Indexing

  • RNA-Binding Proteins (1995-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.452.500
  2. D12.776w.664w.962w.452.500

AMA Style

References

  1. National Library of Medicine. Poly(A)-Binding Protein II. Medical Subject Headings (MeSH). 2026. Unique ID D039103. http://id.nlm.nih.gov/mesh/2026/D039103
  2. Poly(A)-Binding Protein II. In: Wikidata. https://www.wikidata.org/wiki/Q21126792