Chemicals and Drugs

Polypyrimidine Tract-Binding Protein

A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

8 entry terms
  • PTB Protein
  • PTB Splicing Factor
  • p57 Cytoplasmic RNA-Binding Protein
  • pPTB
  • Polypyrimidine Tract Binding Protein
  • Splicing Factor, PTB
  • Tract-Binding Protein, Polypyrimidine
  • p57 Cytoplasmic RNA Binding Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use POLYPYRIMIDINE TRACT-BINDING PROTEIN (NM) 1991-2002

MeSH Record

Previous Indexing

  • RNA-Binding Proteins (1991-2002)
  • Ribonucleoproteins (1991-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.829w.250w
  2. D12.776w.664w.962w.829w.250w

AMA Style

References

  1. National Library of Medicine. Polypyrimidine Tract-Binding Protein. Medical Subject Headings (MeSH). 2026. Unique ID D038941. http://id.nlm.nih.gov/mesh/2026/D038941
  2. Polypyrimidine Tract-Binding Protein. In: Wikipedia. https://en.wikipedia.org/wiki/Polypyrimidine_tract-binding_protein
  3. Polypyrimidine Tract-Binding Protein. In: Wikidata. https://www.wikidata.org/wiki/Q7226903