Chemicals and Drugs

Positive Regulatory Domain I-Binding Factor 1

A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.

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Classification

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See Also

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Synonyms

7 entry terms
  • B Lymphocyte-Induced Maturation Protein 1
  • BLIMP1 Protein
  • PRDI-BF1 Protein
  • PRDM1 Protein
  • B Lymphocyte Induced Maturation Protein 1
  • PRDI BF1 Protein
  • Positive Regulatory Domain I Binding Factor 1

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Repressor Proteins (1994-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.555.500w.800.700
  2. D12.776w.260w.703.650
  3. D12.776w.930w.780.904

AMA Style

References

  1. National Library of Medicine. Positive Regulatory Domain I-Binding Factor 1. Medical Subject Headings (MeSH). 2026. Unique ID D000074462. http://id.nlm.nih.gov/mesh/2026/D000074462
  2. Positive Regulatory Domain I-Binding Factor 1. In: Wikidata. https://www.wikidata.org/wiki/Q21143090