Chemicals and Drugs

Positive Transcriptional Elongation Factor B

A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT KINASE 9 and one of several CYCLINS including TYPE T CYCLINS and cyclin K. It functions by phosphorylating the carboxy-terminal domain of RNA POLYMERASE II.

MeSH Record

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MeSH Record

Synonyms

4 entry terms
  • P-TEFb
  • Positive Transcription Elongation Factor B
  • tat-Associated Kinase
  • tat Associated Kinase

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B (NM) 1996-2003

MeSH Record

Previous Indexing

  • Protein-Serine-Threonine Kinases (1996-2003)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.626w
  2. D12.776w.476.563w.626w
  3. D12.776w.930w.955.500w

AMA Style

References

  1. National Library of Medicine. Positive Transcriptional Elongation Factor B. Medical Subject Headings (MeSH). 2026. Unique ID D042925. http://id.nlm.nih.gov/mesh/2026/D042925
  2. Positive Transcriptional Elongation Factor B. In: Wikipedia. https://en.wikipedia.org/wiki/P-TEFb
  3. Positive Transcriptional Elongation Factor B. In: Wikidata. https://www.wikidata.org/wiki/Q15314917