Structured Summary
Abstract
An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES).
Chemical Identity
Chemical Information
- Molecular Formula
- C23H36O7
- Molecular Weight
- 424.5 g/mol
- CAS Registry No.
- 81093-37-0
- IUPAC Name
- (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
- InChIKey
- TUZYXOIXSAXUGO-PZAWKZKUSA-N
- SMILES
- CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O
- MeSH Unique ID
- D017035
- Source
- PubChem CID 54687
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
38 entry terms
- Eptastatin
- Apo-Pravastatin
- Bristacol
- CS-514
- Elisor
- Lin-Pravastatin
- Lipemol
- Liplat
- Lipostat
- Mevalotin
- Nu-Pravastatin
- Prareduct
- Pravachol
- Pravacol
- Pravasin
- Pravastatin Monosodium Salt, (6 beta)-Isomer
- Pravastatin Sodium
- Pravastatin Sodium Salt
- Pravastatin tert-Octylamine Salt
- Pravastatin, (6 beta)-Isomer
- RMS-431
- SQ-31,000
- SQ-31000
- Selektine
- Vasten
- Apo Pravastatin
- CS 514
- CS514
- Lin Pravastatin
- Nu Pravastatin
- Pravastatin tert Octylamine Salt
- RMS 431
- RMS431
- SQ 31,000
- SQ 31000
- SQ31,000
- SQ31000
- Sodium Salt, Pravastatin
MeSH Record
Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
92; was PRAVASTATIN (NM) 1986-91
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Pravastatin. Medical Subject Headings (MeSH). 2026. Unique ID D017035. http://id.nlm.nih.gov/mesh/2026/D017035
- Pravastatin. In: Wikipedia. https://en.wikipedia.org/wiki/Pravastatin
- Pravastatin. In: Wikidata. https://www.wikidata.org/wiki/Q1240093
- Pravastatin. In: PubChem Compound. CID 54687. https://pubchem.ncbi.nlm.nih.gov/compound/54687