Structured Summary
Abstract
A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.
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Synonyms
5 entry terms
- PBX1 Homeobox Protein
- Pre-B-Cell Leukemia Homeobox 1 Protein
- Homeobox Protein, PBX1
- Pre B Cell Leukemia Homeobox 1 Protein
- Pre B Cell Leukemia Transcription Factor 1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- DNA-Binding Proteins (1993-2017)
- Proto-Oncogene Proteins (1993-2017)
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AMA Style
References
- National Library of Medicine. Pre-B-Cell Leukemia Transcription Factor 1. Medical Subject Headings (MeSH). 2026. Unique ID D000075062. http://id.nlm.nih.gov/mesh/2026/D000075062
- Pre-B-Cell Leukemia Transcription Factor 1. In: Wikidata. https://www.wikidata.org/wiki/Q21108588