Chemicals and Drugs

Pregnancy-Associated alpha 2-Macroglobulins

Large (>160 kDa) glycoproteins with electrophoretic mobility of ALPHA-GLOBULINS, found in high concentration in the plasma of PREGNANT PEOPLE but also in a number of species including mouse, rat, and others (ALPHA-MACROGLOBULINS). In humans, they are always present in the circulation and are nonspecific inhibitors of PROTEINASES, similar to COMPLEMENT PROTEINS (C3; C4; C5).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Large (>160 kDa) glycoproteins with electrophoretic mobility of ALPHA-GLOBULINS, found in high concentration in the plasma of PREGNANT PEOPLE but also in a number of species including mouse, rat, and others (ALPHA-MACROGLOBULINS). In humans, they are always present in the circulation and are nonspecific inhibitors of PROTEINASES, similar to COMPLEMENT PROTEINS (C3; C4; C5).

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

20 entry terms
  • PAAG
  • Pregnancy-Associated alpha 2-Globulins
  • Pregnancy-Associated alpha 2-Glycoproteins
  • alpha(2)-PAG
  • alpha2-PAG
  • Pregnancy Associated alpha 2 Globulins
  • Pregnancy Associated alpha 2 Glycoproteins
  • Pregnancy Associated alpha 2 Macroglobulins
  • alpha 2-Globulins, Pregnancy-Associated
  • alpha 2-Glycoproteins, Pregnancy-Associated
  • alpha 2-Macroglobulins, Pregnancy-Associated
  • alpha2 PAG
  • alpha 2-Glucoprotein
  • alpha 2-Glucoproteins
  • alpha 2-Macroglobulin
  • alpha2-Macroglobulin
  • alpha 2 Glucoprotein
  • alpha 2 Glucoproteins
  • alpha 2 Macroglobulin
  • alpha2 Macroglobulin

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018 (2004); for ALPHA 2-GLUCOPROTEINS use ALPHA-MACROGLOBULINS 1976-2017

MeSH Record

Previous Indexing

  • alpha-Macroglobulins (1976-2003)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.790.720w.100.500
  2. D12.776w.780.675

AMA Style

References

  1. National Library of Medicine. Pregnancy-Associated alpha 2-Macroglobulins. Medical Subject Headings (MeSH). 2026. Unique ID D045384. http://id.nlm.nih.gov/mesh/2026/D045384
  2. Pregnancy-Associated alpha 2-Macroglobulins. In: Wikidata. https://www.wikidata.org/wiki/Q15997057