Chemicals and Drugs

Presenilins

Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.

MeSH Record

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MeSH Record

Synonyms

1 entry terms
  • Presenilin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2007

MeSH Record

Previous Indexing

  • Alzheimer Disease (1995-2006)
  • Membrane Proteins (1995-2006)

MeSH Hierarchy

Tree Number

  1. D12.776w.543w.696w

AMA Style

References

  1. National Library of Medicine. Presenilins. Medical Subject Headings (MeSH). 2026. Unique ID D053763. http://id.nlm.nih.gov/mesh/2026/D053763
  2. Presenilins. In: Wikipedia. https://en.wikipedia.org/wiki/Presenilin
  3. Presenilins. In: Wikidata. https://www.wikidata.org/wiki/Q907198