Chemicals and Drugs

Primaquine

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)

Chemical Identity

Chemical Information

Molecular Formula
C15H21N3O
Molecular Weight
259.35 g/mol
CAS Registry No.
90-34-6
IUPAC Name
4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine
InChIKey
INDBQLZJXZLFIT-UHFFFAOYSA-N
SMILES
CC(CCCN)NC1=C2C(=CC(=C1)OC)C=CC=N2
MeSH Unique ID
D011319
Source
PubChem CID 4908

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • Primacin
  • Primaquine Diphosphate
  • Primaquine Phosphate
  • Diphosphate, Primaquine
  • Phosphate, Primaquine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Hierarchy

Tree Number

  1. D03w.633.100.810.050.650w

MeSH Record

NLM Classification

QV 258

AMA Style

References

  1. National Library of Medicine. Primaquine. Medical Subject Headings (MeSH). 2026. Unique ID D011319. http://id.nlm.nih.gov/mesh/2026/D011319
  2. Primaquine. In: Wikipedia. https://en.wikipedia.org/wiki/Primaquine
  3. Primaquine. In: Wikidata. https://www.wikidata.org/wiki/Q419834
  4. Primaquine. In: PubChem Compound. CID 4908. https://pubchem.ncbi.nlm.nih.gov/compound/4908