Chemicals and Drugs

Prokaryotic Initiation Factor-3

A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

12 entry terms
  • Initiation Factor IF-3
  • Peptide Initiation Factor 3
  • Peptide Initiation Factor IF-3
  • Prokaryotic Peptide Initiation Factor-3
  • TIF IF3
  • Translation Initiation Factor 3
  • IF-3, Initiation Factor
  • Initiation Factor IF 3
  • Initiation Factor-3, Prokaryotic
  • Peptide Initiation Factor IF 3
  • Prokaryotic Initiation Factor 3
  • Prokaryotic Peptide Initiation Factor 3

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use PROKARYOTIC INITIATION FACTOR-3 (NM) 1979-2002; for TIF IF3 & TRANSLATION INITIATION FACTOR 3 use EUKARYOTIC INITIATION FACTOR-3 (NM) 1994-2002

MeSH Record

Previous Indexing

  • Peptide Initiation Factors (1979-2002)

MeSH Hierarchy

Tree Number

  1. D12.776w.835w.725w.934w.750w

AMA Style

References

  1. National Library of Medicine. Prokaryotic Initiation Factor-3. Medical Subject Headings (MeSH). 2026. Unique ID D039665. http://id.nlm.nih.gov/mesh/2026/D039665
  2. Prokaryotic Initiation Factor-3. In: Wikipedia. https://en.wikipedia.org/wiki/Prokaryotic_initiation_factor-3
  3. Prokaryotic Initiation Factor-3. In: Wikidata. https://www.wikidata.org/wiki/Q7249509