Chemicals and Drugs

Proliferating Cell Nuclear Antigen

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

2 entry terms
  • Antigen, Proliferating Cell Nuclear
  • PCNA

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

95; was PROLIFERATING CELL NUCLEAR ANTIGEN (NM) 1983-94

MeSH Record

Previous Indexing

  • Nuclear Proteins (1988-1994)
  • Nucleoproteins (1983-1987)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.660w.740
  2. D23.050w.290.750
  3. D23.101w.140.600

AMA Style

References

  1. National Library of Medicine. Proliferating Cell Nuclear Antigen. Medical Subject Headings (MeSH). 2026. Unique ID D018809. http://id.nlm.nih.gov/mesh/2026/D018809
  2. Proliferating Cell Nuclear Antigen. In: Wikidata. https://www.wikidata.org/wiki/Q24774835