Structured Summary
Abstract
A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.
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Synonyms
11 entry terms
- PAD Type I
- PADI1 Protein
- Peptidyl Arginine Deiminase Type 1
- Peptidyl Arginine Deiminase Type I
- Peptidylarginine Deiminase I
- Peptidylarginine Deiminase Type 1
- Peptidylarginine Deiminase Type I
- Protein Arginine Deiminase 1
- Protein Arginine Deiminase Type 1
- Protein Arginine Deiminase Type I
- Protein-Arginine Deiminase Type I
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
2020 (1999)
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AMA Style
References
- National Library of Medicine. Protein-Arginine Deiminase Type 1. Medical Subject Headings (MeSH). 2026. Unique ID D000080062. http://id.nlm.nih.gov/mesh/2026/D000080062
- Protein-Arginine Deiminase Type 1. In: Wikidata. https://www.wikidata.org/wiki/Q21123684