Chemicals and Drugs

Protein Deglycase DJ-1

A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

10 entry terms
  • DJ-1 Protein
  • DJ-1-PARK7 Protein
  • DJ1 Protein
  • PARK7 Protein
  • Parkinson Protein 7
  • Parkinsonism Associated Deglycase
  • DJ 1 PARK7 Protein
  • DJ 1 Protein
  • DJ-1, Protein Deglycase
  • Deglycase, Parkinsonism Associated

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Intracellular Signaling Peptides and Proteins (1997-2016)
  • Oncogene Proteins (1997-2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.785
  2. D12.776w.705.875

AMA Style

References

  1. National Library of Medicine. Protein Deglycase DJ-1. Medical Subject Headings (MeSH). 2026. Unique ID D000071617. http://id.nlm.nih.gov/mesh/2026/D000071617
  2. Protein Deglycase DJ-1. In: Wikidata. https://www.wikidata.org/wiki/Q21097342