Chemicals and Drugs

Protein Kinase C

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.

MeSH Record

Classification

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MeSH Record

Synonyms

11 entry terms
  • Calcium Phospholipid-Dependent Protein Kinase
  • Calcium-Activated Phospholipid-Dependent Kinase
  • PKC Serine-Threonine Kinase
  • Phospholipid-Sensitive Calcium-Dependent Protein Kinase
  • Calcium Activated Phospholipid Dependent Kinase
  • Calcium Phospholipid Dependent Protein Kinase
  • PKC Serine Threonine Kinase
  • Phospholipid Sensitive Calcium Dependent Protein Kinase
  • Phospholipid-Dependent Kinase, Calcium-Activated
  • Serine-Threonine Kinase, PKC
  • Protein Kinase M

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

86; CALCIUM PHOSPHOLIPID-DEPENDENT PROTEIN KINASE was CALCIUM-PHOSPHOLIPID DEPENDENT PROTEIN KINASE 1986-93

MeSH Record

Previous Indexing

  • Protein Kinases (1973-1985)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.725w
  2. D12.776w.476.563w.725w

AMA Style

References

  1. National Library of Medicine. Protein Kinase C. Medical Subject Headings (MeSH). 2026. Unique ID D011493. http://id.nlm.nih.gov/mesh/2026/D011493
  2. Protein Kinase C. In: Wikipedia. https://en.wikipedia.org/wiki/Protein_kinase_C
  3. Protein Kinase C. In: Wikidata. https://www.wikidata.org/wiki/Q420877