Chemicals and Drugs

Protein Phosphatase 2C

One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.

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Classification

Broader headings

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MeSH Record

Synonyms

29 entry terms
  • PPM1 Magnesium-Dependent Protein Phosphatases
  • PPM1 Protein Phosphatases
  • Ptc2 Phosphatase
  • 2C, Protein Phosphatase
  • PPM1 Magnesium Dependent Protein Phosphatases
  • Phosphatase 2C, Protein
  • Phosphatase, Ptc2
  • Phosphatases, PPM1 Protein
  • Protein Phosphatases, PPM1
  • Magnesium-Dependent Protein Phosphatase 2C beta
  • PP2C beta
  • PP2Cepsilon
  • PP2Cgamma
  • PPM1D Phosphatase
  • PPM1E Phosphatase
  • PPM1G Phosphatase
  • Ppm1b Phosphatase
  • Protein Phosphatase 1D Magnesium-Dependent, delta isoform
  • Protein Phosphatase 2C beta
  • Protein Phosphatase 2C delta
  • Protein Phosphatase 2C epsilon
  • Protein Phosphatase 2C gamma
  • Magnesium Dependent Protein Phosphatase 2C beta
  • Phosphatase, PPM1D
  • Phosphatase, PPM1E
  • Phosphatase, PPM1G
  • Phosphatase, Ppm1b
  • Protein Phosphatase 1D Magnesium Dependent, delta isoform
  • beta, PP2C

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017 (2016)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.625w.716
  2. D12.776w.476.559w.716

AMA Style

References

  1. National Library of Medicine. Protein Phosphatase 2C. Medical Subject Headings (MeSH). 2026. Unique ID D000071636. http://id.nlm.nih.gov/mesh/2026/D000071636
  2. Protein Phosphatase 2C. In: Wikidata. https://www.wikidata.org/wiki/Q24776163