Chemicals and Drugs

Protein Tyrosine Phosphatases

An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.

MeSH Record

Classification

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MeSH Record

Synonyms

15 entry terms
  • PTPase
  • Phosphotyrosine Phosphatase
  • Phosphotyrosyl Protein Phosphatase
  • Protein-Tyrosine Phosphatase
  • Protein-Tyrosine-Phosphatase
  • Tyrosyl Phosphoprotein Phosphatase
  • Phosphatase, Phosphotyrosine
  • Phosphatase, Phosphotyrosyl Protein
  • Phosphatase, Protein-Tyrosine
  • Phosphatase, Tyrosyl Phosphoprotein
  • Phosphatases, Protein Tyrosine
  • Phosphoprotein Phosphatase, Tyrosyl
  • Protein Phosphatase, Phosphotyrosyl
  • Protein Tyrosine Phosphatase
  • Tyrosine Phosphatases, Protein

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

general; prefer specifics

MeSH Record

History Note

2008(1985)

MeSH Record

Previous Indexing

  • Phosphoprotein Phosphatases (1985-1991)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.775w
  2. D12.776w.476.564w

AMA Style

References

  1. National Library of Medicine. Protein Tyrosine Phosphatases. Medical Subject Headings (MeSH). 2026. Unique ID D017027. http://id.nlm.nih.gov/mesh/2026/D017027
  2. Protein Tyrosine Phosphatases. In: Wikipedia. https://en.wikipedia.org/wiki/Protein_tyrosine_phosphatase
  3. Protein Tyrosine Phosphatases. In: Wikidata. https://www.wikidata.org/wiki/Q643602