Chemicals and Drugs

Pyroglutamate Hydrolase

Hydrolyzes pyroglutamic acid in the presence of ATP to glutamate plus ADP and inorganic phosphate. Deficiency leads to pyroglutamic acidurea.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Hydrolyzes pyroglutamic acid in the presence of ATP to glutamate plus ADP and inorganic phosphate. Deficiency leads to pyroglutamic acidurea.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • 5-Oxoprolinase
  • Oxoprolinase
  • 5 Oxoprolinase
  • Hydrolase, Pyroglutamate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91(75); was see under AMIDOHYDROLASES 1975-90

MeSH Record

Previous Indexing

  • Amidohydrolases (1974)
  • Pyrrolidonecarboxylic Acid (1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.277w.087w.760w

AMA Style

References

  1. National Library of Medicine. Pyroglutamate Hydrolase. Medical Subject Headings (MeSH). 2026. Unique ID D011752. http://id.nlm.nih.gov/mesh/2026/D011752
  2. Pyroglutamate Hydrolase. In: Wikipedia. https://en.wikipedia.org/wiki/5-oxoprolinase_(ATP-hydrolysing)
  3. Pyroglutamate Hydrolase. In: Wikidata. https://www.wikidata.org/wiki/Q4639672