Chemicals and Drugs

Pyruvate Dehydrogenase Complex

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

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Synonyms

2 entry terms
  • Complex, Pyruvate Dehydrogenase
  • Dehydrogenase Complex, Pyruvate

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Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

74(73)

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Previous Indexing

  • Oxidoreductases (1966-1972)
  • Pyruvate Oxidase (1966-1972)
  • Pyruvates (1966-1972)

MeSH Hierarchy

Tree Numbers

  1. D05.500w.562w.625w
  2. D08.811w.600w.741w

AMA Style

References

  1. National Library of Medicine. Pyruvate Dehydrogenase Complex. Medical Subject Headings (MeSH). 2026. Unique ID D011768. http://id.nlm.nih.gov/mesh/2026/D011768
  2. Pyruvate Dehydrogenase Complex. In: Wikipedia. https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex
  3. Pyruvate Dehydrogenase Complex. In: Wikidata. https://www.wikidata.org/wiki/Q412856