Chemicals and Drugs

Pyruvate Dehydrogenase (Lipoamide)-Phosphatase

(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. EC 3.1.3.43.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a specific seryl hydroxyl group of pyruvate dehydrogenase, reactivating the enzyme complex. EC 3.1.3.43.

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Classification

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MeSH Record

Synonyms

5 entry terms
  • PDH Phosphatase
  • Pyruvate Dehydrogenase Phosphatase
  • Pyruvate Dehydrogenase Phosphate Phosphatase
  • Phosphatase, PDH
  • Phosphatase, Pyruvate Dehydrogenase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

94; was PYRUVATE DEHYDROGENASE PHOSPHATASE 1975-93 (see under PHOSPHOPROTEIN PHOSPHATASES 1979-90, see under PHOSPHOMONOESTERASES 1975-78)

MeSH Record

Previous Indexing

  • Ketone Oxidoreductases (1973-1974)
  • Phosphatases (1972-1974)
  • Pyruvates (1973-1974)

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References

  1. National Library of Medicine. Pyruvate Dehydrogenase (Lipoamide)-Phosphatase. Medical Subject Headings (MeSH). 2026. Unique ID D011769. http://id.nlm.nih.gov/mesh/2026/D011769
  2. Pyruvate Dehydrogenase (Lipoamide)-Phosphatase. In: Wikipedia. https://en.wikipedia.org/wiki/(pyruvate_dehydrogenase_(acetyl-transferring))-phosphatase
  3. Pyruvate Dehydrogenase (Lipoamide)-Phosphatase. In: Wikidata. https://www.wikidata.org/wiki/Q4544966