Chemicals and Drugs

Quinacrine

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.

Chemical Identity

Chemical Information

Molecular Formula
C23H30ClN3O
Molecular Weight
400.0 g/mol
CAS Registry No.
83-89-6
IUPAC Name
4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
InChIKey
GPKJTRJOBQGKQK-UHFFFAOYSA-N
SMILES
CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC
MeSH Unique ID
D011796
Source
PubChem CID 237

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

22 entry terms
  • Atebrin
  • Mepacrine
  • Acrichine
  • Atabrine
  • Quinacrine Dihydrochloride
  • Quinacrine Dihydrochloride, Dihydrate
  • Quinacrine Dihyrochloride, (R)-Isomer
  • Quinacrine Dihyrochloride, (S)-Isomer
  • Quinacrine Dimesylate
  • Quinacrine Hydrochloride
  • Quinacrine Monoacetate
  • Quinacrine Monohydrochloride
  • Quinacrine Monomesylate
  • Quinacrine, (+-)-Isomer
  • Quinacrine, (R)-Isomer
  • Quinacrine, (S)-Isomer
  • Dihydrochloride, Quinacrine
  • Dimesylate, Quinacrine
  • Hydrochloride, Quinacrine
  • Monoacetate, Quinacrine
  • Monohydrochloride, Quinacrine
  • Monomesylate, Quinacrine

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

CHINACRIN was see QUINACRINE 1977-93

MeSH Hierarchy

Tree Number

  1. D03w.633.300.046w.250w.760w

MeSH Record

NLM Classification

QV 258

AMA Style

References

  1. National Library of Medicine. Quinacrine. Medical Subject Headings (MeSH). 2026. Unique ID D011796. http://id.nlm.nih.gov/mesh/2026/D011796
  2. Quinacrine. In: Wikipedia. https://en.wikipedia.org/wiki/Mepacrine
  3. Quinacrine. In: Wikidata. https://www.wikidata.org/wiki/Q417208
  4. Quinacrine. In: PubChem Compound. CID 237. https://pubchem.ncbi.nlm.nih.gov/compound/237