Chemicals and Drugs

Quinone Reductases

NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.

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Synonyms

3 entry terms
  • Reductases, Quinone
  • Menaquinone Reductases
  • Reductases, Menaquinone

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Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

86(75); was see under NADH, NADPH OXIDOREDUCTASES 1975-85

MeSH Record

Previous Indexing

  • NADH, NADPH Oxidoreductases (1973-1974)
  • Vitamin K (1973-1974)

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References

  1. National Library of Medicine. Quinone Reductases. Medical Subject Headings (MeSH). 2026. Unique ID D011808. http://id.nlm.nih.gov/mesh/2026/D011808
  2. Quinone Reductases. In: Wikipedia. https://en.wikipedia.org/wiki/NADPH:quinone_reductase
  3. Quinone Reductases. In: Wikidata. https://www.wikidata.org/wiki/Q3450201