Structured Summary
Abstract
A dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.
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Classification
Broader headings
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Synonyms
7 entry terms
- AlkB Homolog 5, RNA Demethylase
- Alkylated DNA Repair Protein AlkB Homolog 5
- Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5
- RNA Demethylase ALKBH5
- ALKBH5, RNA Demethylase
- Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 5
- Demethylase ALKBH5, RNA
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Dioxygenases (2011-2016)
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AMA Style
References
- National Library of Medicine. RNA Demethylase AlkB Homolog 5. Medical Subject Headings (MeSH). 2026. Unique ID D000071502. http://id.nlm.nih.gov/mesh/2026/D000071502
- RNA Demethylase AlkB Homolog 5. In: Wikidata. https://www.wikidata.org/wiki/Q21111313