Chemicals and Drugs

RUNX1 Translocation Partner 1 Protein

A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

2 entry terms
  • Eight Twenty One Protein
  • RUNX1T1 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • DNA-Binding Proteins (1993-2017)
  • Proto-Oncogene Proteins (1993-2017)
  • Transcription Factors (2008-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.624.664.700.936
  2. D12.776w.930w.780.625.575

AMA Style

References

  1. National Library of Medicine. RUNX1 Translocation Partner 1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000075142. http://id.nlm.nih.gov/mesh/2026/D000075142
  2. RUNX1 Translocation Partner 1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q24779617