Chemicals and Drugs

Rabeprazole

A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

Chemical Identity

Chemical Information

Molecular Formula
C18H21N3O3S
Molecular Weight
359.4 g/mol
CAS Registry No.
117976-89-3
IUPAC Name
2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methylsulfinyl]-1H-benzimidazole
InChIKey
YREYEVIYCVEVJK-UHFFFAOYSA-N
SMILES
CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
MeSH Unique ID
D064750
Source
PubChem CID 5029

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

12 entry terms
  • 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole
  • 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt
  • Aciphex
  • Dexrabeprazole
  • E 3810
  • E3810
  • LY-307640
  • LY307640
  • Pariet
  • Rabeprazole Sodium
  • LY 307640
  • Sodium, Rabeprazole

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2014

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.640w.074.750w
  2. D03w.383.725w.024.750w
  3. D03w.633.100.103.034.750w

AMA Style

References

  1. National Library of Medicine. Rabeprazole. Medical Subject Headings (MeSH). 2026. Unique ID D064750. http://id.nlm.nih.gov/mesh/2026/D064750
  2. Rabeprazole. In: Wikipedia. https://en.wikipedia.org/wiki/Rabeprazole
  3. Rabeprazole. In: Wikidata. https://www.wikidata.org/wiki/Q3515
  4. Rabeprazole. In: PubChem Compound. CID 5029. https://pubchem.ncbi.nlm.nih.gov/compound/5029