Structured Summary
Abstract
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
6 entry terms
- Benemycin
- Rifampicin
- Rifadin
- Rimactan
- Rimactane
- Tubocin
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
73
MeSH Record
Previous Indexing
- Rifamycins (1966-1972)
MeSH Hierarchy
Tree Numbers
MeSH Record
NLM Classification
QV 268
AMA Style
References
- National Library of Medicine. Rifampin. Medical Subject Headings (MeSH). 2026. Unique ID D012293. http://id.nlm.nih.gov/mesh/2026/D012293
- Rifampin. In: Wikipedia. https://en.wikipedia.org/wiki/Rifampicin
- Rifampin. In: Wikidata. https://www.wikidata.org/wiki/Q422652