Chemicals and Drugs

Rimonabant

A pyrazole and piperidine derivative that acts as a selective cannabinoid type-1 receptor (CB1 RECEPTOR) antagonist. It inhibits the proliferation and maturation of ADIPOCYTES, improves lipid and glucose metabolism, and regulates food intake and energy balance. It is used in the management of OBESITY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pyrazole and piperidine derivative that acts as a selective cannabinoid type-1 receptor (CB1 RECEPTOR) antagonist. It inhibits the proliferation and maturation of ADIPOCYTES, improves lipid and glucose metabolism, and regulates food intake and energy balance. It is used in the management of OBESITY.

Chemical Identity

Chemical Information

Molecular Formula
C22H21Cl3N4O
Molecular Weight
463.8 g/mol
CAS Registry No.
168273-06-1
IUPAC Name
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
InChIKey
JZCPYUJPEARBJL-UHFFFAOYSA-N
SMILES
CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl
MeSH Unique ID
D000077285
Source
PubChem CID 104850

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Acomplia
  • N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride
  • Rimonabant Hydrochloride
  • SR 141716
  • SR 141716A
  • SR-141716A
  • SR141716
  • SR141716A
  • Zimulti

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1994)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.129w.539.888w
  2. D03w.383.621.834w

AMA Style

References

  1. National Library of Medicine. Rimonabant. Medical Subject Headings (MeSH). 2026. Unique ID D000077285. http://id.nlm.nih.gov/mesh/2026/D000077285
  2. Rimonabant. In: Wikipedia. https://en.wikipedia.org/wiki/Rimonabant
  3. Rimonabant. In: Wikidata. https://www.wikidata.org/wiki/Q412529
  4. Rimonabant. In: PubChem Compound. CID 104850. https://pubchem.ncbi.nlm.nih.gov/compound/104850