Chemicals and Drugs

Ryanodine

A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.

Chemical Identity

Chemical Information

Molecular Formula
C25H35NO9
Molecular Weight
493.5 g/mol
CAS Registry No.
15662-33-6
IUPAC Name
[(1R,2R,3S,6S,7S,9S,10R,11S,12R,13S,14R)-2,6,9,11,13,14-hexahydroxy-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl] 1H-pyrrole-2-carboxylate
InChIKey
JJSYXNQGLHBRRK-SFEDZAPPSA-N
SMILES
C[C@H]1CC[C@@]2([C@@]3(C[C@]4([C@@]5([C@]([C@H]([C@@]3([C@]5([C@]2([C@@H]1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O
MeSH Unique ID
D012433
Source
PubChem CID 11317883

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under ALKALOIDS 1975-90

MeSH Record

Previous Indexing

  • Alkaloids (1970-1974)

MeSH Hierarchy

Tree Numbers

  1. D02w.455w.849w.291w.686w
  2. D03w.132w.740w
  3. D03w.383.129w.578.805w

AMA Style

References

  1. National Library of Medicine. Ryanodine. Medical Subject Headings (MeSH). 2026. Unique ID D012433. http://id.nlm.nih.gov/mesh/2026/D012433
  2. Ryanodine. In: Wikipedia. https://en.wikipedia.org/wiki/Ryanodine
  3. Ryanodine. In: Wikidata. https://www.wikidata.org/wiki/Q59851226
  4. Ryanodine. In: PubChem Compound. CID 11317883. https://pubchem.ncbi.nlm.nih.gov/compound/11317883