Chemicals and Drugs

Ryanodine Receptor Calcium Release Channel

A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

19 entry terms
  • Ca Release Channel-Ryanodine Receptor
  • Calcium-Ryanodine Receptor Complex
  • Receptor, Ryanodine
  • Ryanodine Receptor
  • Ca Release Channel Ryanodine Receptor
  • Calcium Ryanodine Receptor Complex
  • Complex, Calcium-Ryanodine Receptor
  • Receptor Complex, Calcium-Ryanodine
  • RyR1
  • RyR2
  • RyR3
  • Ryanodine Receptor 1
  • Ryanodine Receptor 2
  • Ryanodine Receptor 3
  • Ryanodine Receptors
  • Receptor 1, Ryanodine
  • Receptor 2, Ryanodine
  • Receptor 3, Ryanodine
  • Receptors, Ryanodine

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

98; use RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL (NM) 1985-97

MeSH Record

Previous Indexing

  • Calcium Channels (1988-1997)
  • Muscle Proteins (1993-1997)
  • Receptors, Cholinergic (1985-1992)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.530w.400w.150w.800w
  2. D12.776w.210.500.800w
  3. D12.776w.543w.550w.450w.150w.800w
  4. D12.776w.543w.585w.400w.150w.800w

AMA Style

References

  1. National Library of Medicine. Ryanodine Receptor Calcium Release Channel. Medical Subject Headings (MeSH). 2026. Unique ID D019837. http://id.nlm.nih.gov/mesh/2026/D019837
  2. Ryanodine Receptor Calcium Release Channel. In: Wikipedia. https://en.wikipedia.org/wiki/Ryanodine_receptor
  3. Ryanodine Receptor Calcium Release Channel. In: Wikidata. https://www.wikidata.org/wiki/Q416781