Organisms

SCID Mice

Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Mice homozygous for the mutant autosomal recessive gene scid which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

11 entry terms
  • Immunodeficient Mice, Severe Combined
  • Mice, SCID
  • Mouse, SCID
  • Severe Combined Immunodeficient Mice
  • SCID Mouse
  • Mouse, SCID-hu
  • SCID-hu Mice
  • Mice, SCID-hu
  • Mouse, SCID hu
  • SCID hu Mice
  • SCID-hu Mouse

MeSH Record

Aspects Covered

18 allowable subheadings

Indexed with the subheadings abnormalities, anatomy & histology, blood, cerebrospinal fluid, classification, embryology, genetics, growth & development, immunology, injuries, metabolism, microbiology, parasitology, physiology, psychology, surgery, urine, virology.

MeSH Record

Indexing Annotation

NIM with no qualifiers when experimental animal

MeSH Record

History Note

92

MeSH Record

Previous Indexing

  • Mice, Mutant Strains (1983-1991)

MeSH Hierarchy

Tree Number

  1. B01w.050w.150w.900w.649w.313w.992w.635w.505w.500w.550.780w

AMA Style

References

  1. National Library of Medicine. SCID Mice. Medical Subject Headings (MeSH). 2026. Unique ID D016513. http://id.nlm.nih.gov/mesh/2026/D016513
  2. SCID Mice. In: Wikipedia. https://en.wikipedia.org/wiki/Severe_combined_immunodeficient_mice
  3. SCID Mice. In: Wikidata. https://www.wikidata.org/wiki/Q30324043