Chemicals and Drugs

Saccharopine Dehydrogenases

Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form L-LYSINE or NAD+ (EC 1.5.1.9) or NADP+ (EC 1.5.1.10) as an acceptor to form L-GLUTAMATE. Deficiency of this enzyme causes HYPERLYSINEMIAS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form L-LYSINE or NAD+ (EC 1.5.1.9) or NADP+ (EC 1.5.1.10) as an acceptor to form L-GLUTAMATE. Deficiency of this enzyme causes HYPERLYSINEMIAS.

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Classification

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See Also

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Synonyms

13 entry terms
  • Lysine-Ketoglutarate Reductase
  • Saccharopine Dehydrogenase
  • Dehydrogenase, Saccharopine
  • Dehydrogenases, Saccharopine
  • Lysine Ketoglutarate Reductase
  • Reductase, Lysine-Ketoglutarate
  • Lysine-2-Oxoglutarate Reductase
  • Saccharopine Dehydrogenase (NAD+, L-Glutamate Forming)
  • Saccharopine Dehydrogenase (NAD+, L-Lysine Forming)
  • Saccharopine Dehydrogenase (NADP+, L-Glutamate Forming)
  • Saccharopine Dehydrogenase (NADP+, L-Lysine Forming)
  • Lysine 2 Oxoglutarate Reductase
  • Reductase, Lysine-2-Oxoglutarate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

/defic: consider also HYPERLYSINEMIAS

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History Note

91(75); was see under AMINE OXIDOREDUCTASES 1975-90

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Previous Indexing

  • Ketoglutaric Acids (1972-1974)
  • Lysine (1970-1974)
  • Oxidoreductases (1970-1974)

MeSH Hierarchy

Tree Number

  1. D08.811w.682w.662.750

AMA Style

References

  1. National Library of Medicine. Saccharopine Dehydrogenases. Medical Subject Headings (MeSH). 2026. Unique ID D012443. http://id.nlm.nih.gov/mesh/2026/D012443
  2. Saccharopine Dehydrogenases. In: Wikidata. https://www.wikidata.org/wiki/Q76695430