Diseases

Sea-Blue Histiocyte Syndrome

A congenital disease caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES. This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A congenital disease caused by an inborn error involving APOLIPOPROTEINS E leading to abnormal LIPID METABOLISM and the accumulation of GLYCOSPHINGOLIPIDS, particularly SPHINGOMYELINS in the HISTIOCYTES. This disorder is characterized by SPLENOMEGALY and the sea-blue histiocytes in the spleen and bone marrow after May Grunwald staining.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

23 entry terms
  • Histiocyte Syndrome, Sea Blue
  • Histiocyte Syndromes, Sea Blue
  • Histiocytosis, Sea-Blue
  • Sea Blue Histiocytosis
  • Sea-Blue Histiocyte Disease
  • Sea-Blue Histiocytosis
  • Disease, Sea-Blue Histiocyte
  • Diseases, Sea-Blue Histiocyte
  • Histiocyte Disease, Sea-Blue
  • Histiocyte Diseases, Sea-Blue
  • Histiocyte Syndrome, Sea-Blue
  • Histiocyte Syndromes, Sea-Blue
  • Histiocytoses, Sea Blue
  • Histiocytoses, Sea-Blue
  • Histiocytosis, Sea Blue
  • Sea Blue Histiocyte Disease
  • Sea Blue Histiocyte Syndrome
  • Sea Blue Histiocytoses
  • Sea-Blue Histiocyte Diseases
  • Sea-Blue Histiocyte Syndromes
  • Sea-Blue Histiocytoses
  • Syndrome, Sea-Blue Histiocyte
  • Syndromes, Sea-Blue Histiocyte

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1984

MeSH Record

Previous Indexing

  • Histiocytes (1966-1983)

MeSH Hierarchy

Tree Numbers

  1. C10w.228w.140w.163.100.435.825w.775
  2. C15.604w.250w.410w.800
  3. C16w.320w.565w.189.435.825w.775
  4. C16w.320w.565w.398w.641w.803w.850
  5. C16w.320w.565w.595w.554.825w.775
  6. C18.452w.132.100.435.825w.775
  7. C18.452w.584w.563w.641w.803w.850
  8. C18.452w.648w.189.435.825w.775
  9. C18.452w.648w.398w.641w.803w.850
  10. C18.452w.648w.595w.554.825w.775

AMA Style

References

  1. National Library of Medicine. Sea-Blue Histiocyte Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D012618. http://id.nlm.nih.gov/mesh/2026/D012618
  2. Sea-Blue Histiocyte Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q18556319