Chemicals and Drugs

Second-Generation Antidepressive Agents

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

10 entry terms
  • Antidepressants, Atypical
  • Antidepressive Agents, Second-Generation
  • Antidepressive Drugs, Second-Generation
  • Atypical Antidepressants
  • Agents, Second-Generation Antidepressive
  • Antidepressive Agents, Second Generation
  • Antidepressive Drugs, Second Generation
  • Drugs, Second-Generation Antidepressive
  • Second Generation Antidepressive Agents
  • Second-Generation Antidepressive Drugs

MeSH Record

Aspects Covered

22 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Antidepressive Agents (1977-1994)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Second-Generation Antidepressive Agents. Medical Subject Headings (MeSH). 2026. Unique ID D018687. http://id.nlm.nih.gov/mesh/2026/D018687
  2. Second-Generation Antidepressive Agents. In: Wikidata. https://www.wikidata.org/wiki/Q50430246