Chemicals and Drugs

Secretory Component

The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The extracellular moiety of the POLYMERIC IMMUNOGLOBULIN RECEPTOR found alone or complexed with IGA or IGM, in a variety of external secretions (tears, bile, colostrum.) Secretory component is derived by proteolytic cleavage of the receptor during transcytosis. When immunoglobulins IgA and IgM are bound to the receptor, during their transcytosis secretory component becomes covalently attached to them generating SECRETORY IMMUNOGLOBULIN A or secretory IMMUNOGLOBULIN M.

MeSH Record

Classification

Broader headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • Secretory Piece

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacology, physiology, poisoning, radiation effects, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91(76); was see under IMMUNOGLOBULIN FRAGMENTS 1976-90

MeSH Record

Previous Indexing

  • Colostrum (1973-1975)
  • IgA (1973-1975)
  • Immunoglobulin Fragments (1973-1975)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.124w.486.485.114w.619w.026w.030.500w
  2. D12.776w.124w.486.485.705.875w
  3. D12.776w.124w.790.651.114w.619w.026w.030.500w
  4. D12.776w.124w.790.651.705.875w
  5. D12.776w.377w.715.548.114w.619w.026w.030.500w
  6. D12.776w.377w.715.548.705.875w

AMA Style

References

  1. National Library of Medicine. Secretory Component. Medical Subject Headings (MeSH). 2026. Unique ID D012635. http://id.nlm.nih.gov/mesh/2026/D012635
  2. Secretory Component. In: Wikipedia. https://en.wikipedia.org/wiki/Secretory_component
  3. Secretory Component. In: Wikidata. https://www.wikidata.org/wiki/Q7444455