Structured Summary
Abstract
Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
4 entry terms
- PTTG Protein
- Pituitary Tumor-Transforming Gene Protein
- Pituitary Tumor-Transforming Proteins
- Pituitary Tumor Transforming Proteins
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2014
MeSH Record
Previous Indexing
- Neoplasm Proteins (1997-2013)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Securin. Medical Subject Headings (MeSH). 2026. Unique ID D064249. http://id.nlm.nih.gov/mesh/2026/D064249
- Securin. In: Wikipedia. https://en.wikipedia.org/wiki/Securin
- Securin. In: Wikidata. https://www.wikidata.org/wiki/Q6740686