Chemicals and Drugs

Selective Estrogen Receptor Modulators

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

See Also

MeSH Record

Synonyms

5 entry terms
  • Estrogen Receptor Modulator, Selective
  • Estrogen Receptor Modulators, Selective
  • SERM
  • SERMs
  • Selective Estrogen Receptor Modulator

MeSH Record

Aspects Covered

23 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

do not confuse with ESTROGEN RECEPTOR MODULATORS

MeSH Record

History Note

2000

MeSH Record

Previous Indexing

  • Receptors, Estrogen (1996-1999)

MeSH Hierarchy

Tree Numbers

  1. D06.347w.360.827w
  2. D27.505.696.399.450w.360.827w

AMA Style

References

  1. National Library of Medicine. Selective Estrogen Receptor Modulators. Medical Subject Headings (MeSH). 2026. Unique ID D020845. http://id.nlm.nih.gov/mesh/2026/D020845
  2. Selective Estrogen Receptor Modulators. In: Wikipedia. https://en.wikipedia.org/wiki/Selective_estrogen_receptor_modulator
  3. Selective Estrogen Receptor Modulators. In: Wikidata. https://www.wikidata.org/wiki/Q903917