Phenomena and Processes

Senescence-Associated Secretory Phenotype

A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

7 entry terms
  • Senescent Cell SASP
  • Phenotype, Senescence-Associated Secretory
  • SASP, Senescent Cell
  • SASPs, Senescent Cell
  • Secretory Phenotype, Senescence-Associated
  • Senescence Associated Secretory Phenotype
  • Senescent Cell SASPs

MeSH Record

Aspects Covered

5 allowable subheadings

Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2022; use CELLULAR SENESCENCE 2018-2021

MeSH Hierarchy

Tree Numbers

  1. G04.043w.445w
  2. G07.345.124w.130w.445w

AMA Style

References

  1. National Library of Medicine. Senescence-Associated Secretory Phenotype. Medical Subject Headings (MeSH). 2026. Unique ID D000089262. http://id.nlm.nih.gov/mesh/2026/D000089262
  2. Senescence-Associated Secretory Phenotype. In: Wikipedia. https://en.wikipedia.org/wiki/Senescence-associated_secretory_phenotype
  3. Senescence-Associated Secretory Phenotype. In: Wikidata. https://www.wikidata.org/wiki/Q85800340