Diseases

Serotonin Syndrome

An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.

MeSH Record

Classification

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MeSH Record

See Also

MeSH Record

Synonyms

3 entry terms
  • Serotonin Syndromes
  • Syndrome, Serotonin
  • Syndromes, Serotonin

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1999

MeSH Record

Previous Indexing

  • Serotonin (1980-1992)
  • Serotonin Uptake Inhibitors/adverse effects (1993-1998)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Serotonin Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D020230. http://id.nlm.nih.gov/mesh/2026/D020230
  2. Serotonin Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Serotonin_syndrome
  3. Serotonin Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q616181