Chemicals and Drugs

Short Stature Homeobox Protein

A homeodomain protein that is highly expressed in the nuclei of skeletal muscle, bone marrow, and osteogenic cells and has critical roles in growth and development. Its gene resides within PSEUDOAUTOSOMAL REGION 1 of X and Y chromosomes and mutations are associated with several growth disorders including LERI-WEIL SYNDROME; LANGER MESOMELIC DYSPLASIA; and SHORT STATURE, IDIOPATHIC, X-LINKED.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A homeodomain protein that is highly expressed in the nuclei of skeletal muscle, bone marrow, and osteogenic cells and has critical roles in growth and development. Its gene resides within PSEUDOAUTOSOMAL REGION 1 of X and Y chromosomes and mutations are associated with several growth disorders including LERI-WEIL SYNDROME; LANGER MESOMELIC DYSPLASIA; and SHORT STATURE, IDIOPATHIC, X-LINKED.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • GCFX Protein
  • PHOG Protein
  • SHOX Protein
  • SHOXY Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Homeodomain Proteins (1997-2017)

MeSH Hierarchy

Tree Number

  1. D12.776w.260w.400.859w

AMA Style

References

  1. National Library of Medicine. Short Stature Homeobox Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000074122. http://id.nlm.nih.gov/mesh/2026/D000074122
  2. Short Stature Homeobox Protein. In: Wikipedia. https://en.wikipedia.org/wiki/Short-stature_homeobox_gene
  3. Short Stature Homeobox Protein. In: Wikidata. https://www.wikidata.org/wiki/Q2206154