Structured Summary
Abstract
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
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Synonyms
6 entry terms
- Schwartzman Phenomenon
- Schwartzman Reaction
- Shwartzman Reaction
- Phenomenon, Schwartzman
- Phenomenon, Shwartzman
- Schwartzman Reactions
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35 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
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WH 312
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References
- National Library of Medicine. Shwartzman Phenomenon. Medical Subject Headings (MeSH). 2026. Unique ID D012790. http://id.nlm.nih.gov/mesh/2026/D012790
- Shwartzman Phenomenon. In: Wikipedia. https://en.wikipedia.org/wiki/Shwartzman_phenomenon
- Shwartzman Phenomenon. In: Wikidata. https://www.wikidata.org/wiki/Q3454355