Diseases

Shy-Drager Syndrome

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

24 entry terms
  • Autonomic Failure, Progressive
  • Dysautonomia-Orthostatic Hypotension Syndrome
  • Idiopathic Orthostatic Hypotension, Shy-Drager Type
  • Orthostatic Hypotension, Dysautonomic
  • Syndrome, Dysautonomia-Orthostatic Hypotension
  • Autonomic Failures, Progressive
  • Dysautonomia Orthostatic Hypotension Syndrome
  • Dysautonomia-Orthostatic Hypotension Syndromes
  • Dysautonomic Orthostatic Hypotension
  • Dysautonomic Orthostatic Hypotensions
  • Failure, Progressive Autonomic
  • Failures, Progressive Autonomic
  • Hypotension Syndrome, Dysautonomia-Orthostatic
  • Hypotension Syndromes, Dysautonomia-Orthostatic
  • Hypotension, Dysautonomic Orthostatic
  • Hypotensions, Dysautonomic Orthostatic
  • Idiopathic Orthostatic Hypotension, Shy Drager Type
  • Orthostatic Hypotensions, Dysautonomic
  • Progressive Autonomic Failure
  • Progressive Autonomic Failures
  • Shy Drager Syndrome
  • Syndrome, Dysautonomia Orthostatic Hypotension
  • Syndrome, Shy-Drager
  • Syndromes, Dysautonomia-Orthostatic Hypotension

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

1991(1981)

MeSH Record

Previous Indexing

  • Hypotension, Orthostatic (1966-1980)
  • Nervous System Diseases (1966-1980)

MeSH Hierarchy

Tree Numbers

  1. C10w.177.575w.550w.750w
  2. C10w.228w.140w.079w.612w.700w
  3. C10w.228w.662w.550w.700w
  4. C14w.907w.514w.741w

MeSH Record

NLM Classification

WL 358.5

AMA Style

References

  1. National Library of Medicine. Shy-Drager Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D012791. http://id.nlm.nih.gov/mesh/2026/D012791
  2. Shy-Drager Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Shy-drager_syndrome
  3. Shy-Drager Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q2280546