Diseases

Silver-Russell Syndrome

Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.

MeSH Record

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MeSH Record

See Also

MeSH Record

Synonyms

12 entry terms
  • Russell Silver Syndrome
  • Russell-Silver Syndrome
  • Silver Russell Dwarfism
  • Silver-Russell Dwarfism
  • Dwarfism, Silver Russell
  • Dwarfism, Silver-Russell
  • Russell-Silver Syndromes
  • Silver Russell Syndrome
  • Syndrome, Russell Silver
  • Syndrome, Russell-Silver
  • Syndrome, Silver-Russell
  • Syndromes, Russell-Silver

MeSH Record

Aspects Covered

34 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2010

MeSH Record

Previous Indexing

  • Growth Disorders (1970-2009)

MeSH Hierarchy

Tree Numbers

  1. C05w.660w.207w.925w
  2. C16w.131w.077w.855w
  3. C16w.131w.260w.870w
  4. C16w.320w.180w.870w
  5. C16w.320w.240w.937w
  6. C16w.320w.447.750w

AMA Style

References

  1. National Library of Medicine. Silver-Russell Syndrome. Medical Subject Headings (MeSH). 2026. Unique ID D056730. http://id.nlm.nih.gov/mesh/2026/D056730
  2. Silver-Russell Syndrome. In: Wikipedia. https://en.wikipedia.org/wiki/Silver%E2%80%93Russell_syndrome
  3. Silver-Russell Syndrome. In: Wikidata. https://www.wikidata.org/wiki/Q2142496