Chemicals and Drugs

Single-Strand Specific DNA and RNA Endonucleases

Enzymes that catalyze the endonucleolytic cleavage of single-stranded regions of DNA or RNA molecules while leaving the double-stranded regions intact. They are particularly useful in the laboratory for producing blunt-ended DNA molecules from DNA with single-stranded ends and for sensitive GENETIC TECHNIQUES such as NUCLEASE PROTECTION ASSAYS that involve the detection of single-stranded DNA and RNA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Enzymes that catalyze the endonucleolytic cleavage of single-stranded regions of DNA or RNA molecules while leaving the double-stranded regions intact. They are particularly useful in the laboratory for producing blunt-ended DNA molecules from DNA with single-stranded ends and for sensitive GENETIC TECHNIQUES such as NUCLEASE PROTECTION ASSAYS that involve the detection of single-stranded DNA and RNA.

MeSH Record

Classification

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MeSH Record

Synonyms

1 entry terms
  • Single Strand Specific DNA and RNA Endonucleases

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2009(1990)

MeSH Record

Previous Indexing

  • Endonucleases (1973-1989)
  • Phosphodiesterases (1972)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.335w.350w.700
  2. D08.811w.277w.352w.355w.325w.700
  3. D08.811w.277w.352w.355w.350w.820
  4. D08.811w.277w.352w.700w.350w.850

AMA Style

References

  1. National Library of Medicine. Single-Strand Specific DNA and RNA Endonucleases. Medical Subject Headings (MeSH). 2026. Unique ID D015719. http://id.nlm.nih.gov/mesh/2026/D015719
  2. Single-Strand Specific DNA and RNA Endonucleases. In: Wikidata. https://www.wikidata.org/wiki/Q78458932