Chemicals and Drugs

Sofosbuvir

A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.

Chemical Identity

Chemical Information

Molecular Formula
C22H29FN3O9P
Molecular Weight
529.5 g/mol
CAS Registry No.
1190307-88-0
IUPAC Name
propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
InChIKey
TTZHDVOVKQGIBA-IQWMDFIBSA-N
SMILES
C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
MeSH Unique ID
D000069474
Source
PubChem CID 45375808

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
  • GS-7977
  • PSI 7977
  • PSI-7977
  • PSI7977
  • Sovaldi
  • 7977, PSI
  • GS 7977
  • GS7977

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2010)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.742.686.850.877w.500w
  2. D13.695w.740.850.877w.500w
  3. D13.695w.827w.919.877w.500w

AMA Style

References

  1. National Library of Medicine. Sofosbuvir. Medical Subject Headings (MeSH). 2026. Unique ID D000069474. http://id.nlm.nih.gov/mesh/2026/D000069474
  2. Sofosbuvir. In: Wikipedia. https://en.wikipedia.org/wiki/Sofosbuvir
  3. Sofosbuvir. In: Wikidata. https://www.wikidata.org/wiki/Q2502747
  4. Sofosbuvir. In: PubChem Compound. CID 45375808. https://pubchem.ncbi.nlm.nih.gov/compound/45375808