Chemicals and Drugs

Somatostatin

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • Cyclic Somatostatin
  • SRIH-14
  • Somatostatin, Cyclic
  • Somatostatin-14
  • Somatotropin Release-Inhibiting Factor
  • Somatotropin Release-Inhibiting Hormone
  • Somatostatin 14
  • Somatotropin Release Inhibiting Factor
  • Somatotropin Release Inhibiting Hormone
  • Somatofalk
  • Stilamin

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

99

MeSH Record

Previous Indexing

  • Somatotropin Releasing Hormone/antagonists & inhibitors (1974)
  • Somatotropin/antagonists & inhibitors (1973-1974)

MeSH Hierarchy

Tree Numbers

  1. D06.472w.699w.327.700.875w
  2. D06.472w.699w.587.780w
  3. D12.644w.400w.400.700.875w
  4. D12.644w.548w.365.700.875w
  5. D12.644w.548w.586.780w
  6. D12.776w.631w.650w.405.700.875w

MeSH Record

NLM Classification

WK 515

AMA Style

References

  1. National Library of Medicine. Somatostatin. Medical Subject Headings (MeSH). 2026. Unique ID D013004. http://id.nlm.nih.gov/mesh/2026/D013004
  2. Somatostatin. In: Wikipedia. https://en.wikipedia.org/wiki/Somatostatin_family
  3. Somatostatin. In: Wikidata. https://www.wikidata.org/wiki/Q24778427