Structured Summary
Abstract
An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.
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Classification
Broader headings
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See Also
MeSH Record
Synonyms
4 entry terms
- Sphingomyelin Cholinephosphohydrolase
- Sphingomyelin Cleaving Enzyme
- Sphingomyelinase
- Sphingomyelinase C
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
/defic: consider also NIEMANN-PICK DISEASE
MeSH Record
History Note
91(75); was see under PHOSPHODIESTERASES 1975-90
MeSH Record
Previous Indexing
- Phosphodiesterases (1973-1974)
- Sphingomyelins (1973-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Sphingomyelin Phosphodiesterase. Medical Subject Headings (MeSH). 2026. Unique ID D013108. http://id.nlm.nih.gov/mesh/2026/D013108
- Sphingomyelin Phosphodiesterase. In: Wikipedia. https://en.wikipedia.org/wiki/Sphingomyelin_phosphodiesterase
- Sphingomyelin Phosphodiesterase. In: Wikidata. https://www.wikidata.org/wiki/Q413230