Chemicals and Drugs

Staurosporine

An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)

Chemical Identity

Chemical Information

Molecular Formula
C28H26N4O3
Molecular Weight
466.5 g/mol
CAS Registry No.
62996-74-1
IUPAC Name
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
InChIKey
HKSZLNNOFSGOKW-FYTWVXJKSA-N
SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
MeSH Unique ID
D019311
Source
PubChem CID 44259

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

1 entry terms
  • 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

97; was STAUROSPORINE (NM) 1977-96

MeSH Record

Previous Indexing

  • Alkaloids (1977-1996)

MeSH Hierarchy

Tree Numbers

  1. D03w.132w.436w.750w
  2. D03w.633.100.473.144.750w
  3. D03w.633.100.473.402w.750w
  4. D03w.633.100.496.500.500w.750w
  5. D03w.633.300.148.750w

AMA Style

References

  1. National Library of Medicine. Staurosporine. Medical Subject Headings (MeSH). 2026. Unique ID D019311. http://id.nlm.nih.gov/mesh/2026/D019311
  2. Staurosporine. In: Wikipedia. https://en.wikipedia.org/wiki/Staurosporine
  3. Staurosporine. In: Wikidata. https://www.wikidata.org/wiki/Q5957181
  4. Staurosporine. In: PubChem Compound. CID 44259. https://pubchem.ncbi.nlm.nih.gov/compound/44259